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Degenerative myelopathy (DM) is a progressive neurological disorder that affects the spinal cord in dogs, leading to a gradual loss of mobility. It is often compared to amyotrophic lateral sclerosis (ALS) in humans and is primarily seen in older dogs, particularly those over the age of 7.
DM is believed to be caused by a genetic mutation in the SOD1 gene, which is associated with the degeneration of nerve fibers in the spinal cord. Dogs that inherit two copies of this mutated gene are at a higher risk of developing the condition, although not all will necessarily show symptoms. Breeds commonly affected include:
Environmental factors may also contribute to the onset of the disease.
The symptoms of degenerative myelopathy typically develop slowly and may include:
As the disease progresses, dogs may lose the ability to walk, and eventually, the condition can lead to paralysis of the hind limbs and loss of bladder and bowel control.
Degenerative myelopathy is a progressive condition, and most dogs become paraplegic within six months to a year after the onset of symptoms. While the disease is not typically painful, it significantly impacts the dog’s quality of life. Many dogs are humanely euthanized within 6 to 12 months of diagnosis due to the debilitating nature of the disease.
Diagnosing DM involves a combination of clinical signs, breed predisposition, and ruling out other conditions that may cause similar symptoms. Tests may include:
Currently, there is no cure for degenerative myelopathy, but management strategies can help maintain quality of life. These may include:
Degenerative myelopathy is a challenging condition for both dogs and their owners. While there is no cure, early diagnosis and a proactive management approach can help improve the quality of life for affected pets. Regular veterinary care and support from pet owners are essential in navigating this progressive disease.
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